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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well lead to a rise in methadone plasma concentrations, which could induce probably fatal respiratory depression. On top of that, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also bring about a rise in